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BUCKLER LAB
PlantCaduceus, abbreviated as PlantCAD, is a DNA language model trained to capture 160 million years of plant genome evolution. Built on the state-of-the-art Mamba architecture, it models diverse plant genomes at single-nucleotide resolution using a masked language modeling objective. By learning patterns of evolutionary conservation and divergence, PlantCAD enables cross-species genome annotation and deleterious mutation prediction. Its versatility makes it a powerful AI tool for both basic plant genomics and applied crop improvement.

For more information on how to get started, please visit our GitHub repository.
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